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Project promotion materials:

Project Members:

Mike Baker (Project Manager, mbaker@cmri.org.au)

ANDS Contact:

Alan Glixman (alan.glixman@ands.org.au)

Project Status:

In Progress

Children's Medical Research Institute - ProCan Data Management

Children's Medical Research Institute

Project Description

The Children’s Medical Research Institute (CMRI) is dedicated to advancing the treatment and prevention of childhood diseases, so every child has the opportunity for a healthy start to life. CMRI pioneered microsurgery, immunisations against lethal childhood illnesses and care for premature babies, all of which has improved the lives of countless Australian children over the last 50 years.

Today, CMRI is the site of world-leading research in areas such as cancer, neurobiology, embryology and gene therapy. CMRI has a number of labs and major facilities involved in researching childhood and adult cancer, one of these facilities is the ProCan Facility, which is a world-first initiative that was established with a $10 million grant from the Australian CancerResearch Foundation (ACRF). ProCan, The ACRF International Centre for the Proteome of Human Cancer is set to launch in September 2016.

New technology called PCT-SWATH mass spectrometry will be used to rapidly and simultaneously measure the precise levels of many thousands of proteins in very small cancer biopsies. Working with leading cancer researchers throughout Australia and around the world, the Centre will analyse about 70,000 samples of all types of cancer, starting with childhood leukaemia. Advanced computer analysis techniques will then be used to compare the protein data with the information that is already available for each cancer, including clinical records such as pathology test results, genetic analyses, genome sequencing, and any previous responses to cancer treatment.

This proteo-genomics approach to understanding cancer is crucial to speeding up the search for cures, and towards this end, ProCan signed an MOU with the United States' National Cancer Institute as part of Vice President Joe Biden's Cancer Moonshot Initiative. The information generated by ProCan will be free for anyone to access. This will help scientists all over the world studying cancer. What’s more, the library of information created will be a point of reference that can be used now and in the future to aid rapid diagnosis and treatment planning.

This initiative will raise the current laboratory based capability of the ProCan Facility to an industrial scale and enable transformation of 70,000 physical samples to create a new national resource –a Library of Proteomes of Cancer. Enabling the library of proteomes of cancer to build the Library of Proteomes of Cancer will require a data management framework at the CMRI ProCan facility which will tackle questions such as policy and guidelines, licensing, capturing associated information and quality information, citation, etc.. This will contribute to the integrity and longevity of the research data, increase the likelihood of reproducibility of research, enable opportunities for collaboration and enable researchers to receive credit through citation.

Aims of the project and expected impact

The project aims to:
● Support the building of the ProCan library of proteomes of cancer. This rich collection of proteome data will help scientists all over the world studying cancer and will be a point of reference that can be used now and in the future to aid rapid diagnosis and treatment. Having such a library will allow CMRI to demonstrate its leading position in this research area and continue and grow international research collaboration.

●Develop a supporting framework for the establishment of the proteome library including policies and guidelines, capturing associated quality information. This will lead to a well-managed data collection coming out of the ProCan facility and an understanding and experience in tackling research data management challenges within CMRI.

●Ensure that relevant quality information is captured in the pipeline and is available in the resultant ProCan Proteomics library. This will lead to a high quality data library to the benefit of research worldwide. Having the quality information associated with the information will increase the re-usability of the data.